New Player of ncRNAs: Long Non-coding RNAs
نویسندگان
چکیده
منابع مشابه
New Player of ncRNAs: Long Non-coding RNAs
The mechanism underlying the functions of non-protein coding RNAs (ncRNAs or npcRNAs) that have no or little protein-coding potential is a fascinating area of research [1]. Based on transcript length, ncRNAs are classified as short (<200 nt) and long ncRNAs (lncRNAs; >200 nt). The recent high-throughput analysis such as cDNA/EST in silico mining, whole-genome tilling array and RNA-sequencing (R...
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Protein-coding genes account for only a small fraction of the human genome and most of the genomic sequences are transcriptionally silent, but recent observations indicate significant functional elements, including non-coding protein transcripts in the human genome. Long non-coding RNAs (lncRNAs) have been defined as transcripts of >200 nucleotides without protein-coding capacity that perform t...
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DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous conditions. Such abrasions have deleterious effect in cells leading to genome rearrangements and cell death. A number of repair systems including homologous recombination (HR) and non-homologous end-joining (NHEJ) have been evolved to minimize the fatal effe...
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ژورنال
عنوان ژورنال: Journal of Analytical & Pharmaceutical Research
سال: 2016
ISSN: 2473-0831
DOI: 10.15406/japlr.2016.03.00064